Hyperinsulinemia in Obesity, Inflammation, and Cancer

Apolipoprotein E2 Accentuates Postprandial Inflammation and Diet-Induced Obesity to Promote Hyperinsulinemia in Mice

Genetic studies have revealed the association between the ε2 allele of the apolipoprotein E (apoE) gene and greater risk of metabolic diseases. This study compared C57BL/6 mice in which the endogenous mouse gene has been replaced by the human APOE2 or APOE3 gene (APOE2 and APOE3 mice) to identify the mechanism underlying the relationship between ε2 and obesity and diabetes. In comparison with A...

Hyperinsulinemia: a Cause of Obesity?

PURPOSE OF REVIEW This perspective is motivated by the need to question dogma that does not work: that the problem is insulin resistance (IR). We highlight the need to investigate potential environmental obesogens and toxins. RECENT FINDINGS The prequel to severe metabolic disease includes three interacting components that are abnormal: (a) IR, (b) elevated lipids and (c) elevated basal insul...

A causal role for hyperinsulinemia in obesity.

Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and conversely, dietary and pharmacological manipulations that reduce insulin have occasionally been reported to cause weight loss. However, the causal role of insulin hypersecretion in the development of mammalian obesity remain...

Editorial: Cytokines in inflammation, aging, cancer and obesity.

The interaction of obesity and inflammation in breast cancer

Obesity and overweight have closely considered with several chronic diseases. Evidence of this field has demonstrated that significantly impact on the multiple cancers progression, such as breast cancer, prostate cancer, hepatocellular carcinoma, pancreatic cancer and cervical cancer. Epidemiological studies have shown that there is about 20% of cancer related to obesity, which were affected by...